罗哌卡因复合舒芬太尼在产妇分娩镇痛中的应用

Application of ropivacaine with sufentanil for patient-controlled epidural analgesia:a randomized clinical trail

目的观察不同浓度的罗哌卡因复合舒芬太尼用于产妇分娩硬膜外自控镇痛的临床效果。方法 150例拟行硬膜外分娩镇痛的初产妇随机分为5组,每组30例,分别予以0.05%(A组)、0.075%(B组)、0.1%(C组)、0.125%(D组)、0.15%(E组)的罗哌卡因+0.5μg/ml舒芬太尼进行硬膜外镇痛。结果镇痛有效率分别为47%,67%,77%,83%,87%。E组有1例运动阻滞发生。结论 0.1%～0.125%罗哌卡因复合0.5μg/ml舒芬太尼能够为产妇分娩提供安全可靠的镇痛。

Objective This study aimed to compare the analgesic efficacy,motor block and side effects of ropivacaine at lower concentrations for patient-controlled epidural labor analgesia.MethodsOne hundred and fifty nulliparous parturients were enrolled in this randomized clinical trial.A concentration of 0.05%,0.075%,0.1%,0.125% or 0.15% of ropivacaine with sufentanil 0.5 μg/ml was epidurally administered by patient-controlled analgesia mode.ResultsA significantly less number of effective analgesia were observed in the concentration of 0.05% and 0.075% than those of ≥0.1% within each group（P〈0.05）.Conclusion Using patient-controlled epidural analgesia,ropivacaine of 0.1% or 0.125% with sufentanil of 0.5μg/ml produce good analgesia and safety for labor analgesia.