骨及软组织炎症性病变的^(31)P MR波谱代谢特征初探

Study of ^(31)P MR spectroscopy metabolic characteristics of bone and soft inflammation

目的初步探讨活体31P MR波谱(31P MRS)在骨炎症性病变中的代谢特征。方法对32例健康志愿者、26例骨及软组织炎症分别行常规X线、MRI与31P MRS检查,测定波谱中各代谢产物的峰下面积,计算各代谢产物间的比值。统计学采用独立样本t检验,判断炎症组与对照组之间是否存在差异。结果炎症组PDE/β-ATP(2.25±0.39)、Pi/β-ATP(1.52±0.47)明显高于对照组(P均<0.05),但PME/β-ATP(0.18±0.11)值不高;对照组低能磷酸盐(LEP)/总31P代谢物(T31P)(0.10±0.02)、PCr/T31P(0.45±0.03)、ATP/T31 P(0.45±0.03)与炎症组之间差异有统计学意义(P<0.01)。结论组织中PDE和Pi的升高,并不伴PME升高的31P MR波谱代谢特征对骨及软组织病变的初步定性诊断有重要意义。MRS技术与常规X线、MRI相结合,将有助于临床对骨炎症性病变的鉴别。

Objective To explore the value of ^31P magnetic resonance spectroscopy（^31P MRS） of bone and soft inflammation.MethodsRadiography,MRI and ^31P MRS were performed on 22 bone and soft-tissue inflammation patients and 32 healthy volunteers.The spectra were analyzed by measuring the areas under the peaks of various metabolites.The data were analyzed by t test.ResultsAnalysis of the ^31P MRS data suggested differences among theinflammation and the healthy group.The mean of PDE/β-ATP（2.25±0.39）、Pi/β-ATP（1.52±0.47）in inflammation group was higher than the control group（P〈0.05）,but the ratio of PME/β-ATP（0.18±0.11）was not increasing.The LEP/ T^31P（0.10±0.02）、PCr/T^31P（0.45±0.03）and ATP/ T^31P（0.45±0.03）ratios in control group were significantly different from the experimental group（P〈0.01）.ConclusionThe significant increase of PDE、Pi and no increase of PME intracellular is of great value in diagnosis of bone and soft inflammation.Combined conventional radiography and MRI,^31P MRS would be a simple,non-invasive and effective diagnostic method.