蜂蜡素固体分散体对高脂血症大鼠脂代谢的影响

Effect of Fenglasu solid dispersion on lipid metabolism in hyperlipoidemia rats

目的:观察蜂蜡素(Fenglasu,FLS)及蜂蜡素固体分散体(Fenglasu solid dispersion,FLS-SD)对高脂血症大鼠脂代谢的影响。方法:高脂饲料喂养制备高脂血症大鼠模型,分别给予高,中,低剂量FLS及FLS-SD(50,100,200 mg·kg-1·d-1),测定大鼠血清中胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、载脂蛋白A1(apoA1)、载脂蛋白B100(apoB100)含量,计算LDL-C/HDL-C和apoA1/apoB100的比值。结果:FLS及FLS-SD均呈剂量和时间依赖性显著降低高血脂大鼠血清TC,TG,LDL-C,apoB100和LDL-C/HDL-C比值,显著升高HDL-C、apoA1和apoA1/apoB100比值,且FLS-SD作用强于FLS。结论:FLS-SD可有效调节高脂血症大鼠的脂代谢紊乱。

Objective： To observe the effects of Fenglasu （FLS） and Fenglasu solid dispersion （FLS-SD） on lipid metabolism in byperlipoidemia rats. Methods： Hyperlipoidemia rat was induced by feeding with high lipid diets, and FLS and FLS-SD （50, 100, 200 mg·kg^-l·d^-1） were preventively administered. TC, TG, LDL-C, HDL-C, apoA1, and apoB100 were determined, LDL-C/HDL-C and apoA1/apoBlo0 were calculated. Results： FLS and FLS-SD decreased the levels of TC, TG, LDL-C, apoB1oo , and LDL-C/HDL-C ; increased the levels of HDL- C, apoA1 , apoA1/apoBl00 in dose- and time-dependent manners. The effect of FLS-SD was more potent than that of FLS. Conclusion： FLS-SD can effectively adjust lipid metabolic disorder in hyperlipoidemia rats.