转基因棉籽亚慢性毒性的研究

Sub-Chronic Toxicity Study of Transgenic Cottonseed in SD Rats

目的:转基因棉籽对SD大鼠亚慢性毒性的研究。方法:选取出生6-8周的SPF级SD大鼠140只,雌雄各半,按体重随机分成7组,分别连续饲喂含普通棉籽5%、2.5%和1.25%的饲料和含转基因棉籽5%、2.5%和1.25%的饲料以及基础饲料30天。实验过程中监测动物体重、进食量和进水量,结束后分别测定各组动物的血常规、血生化、脏体指数等指标。结果:实验期间各组动物均生长发育良好,无中毒死亡现象发生。实验组实验动物的各项指标与对照组相比,无显著性差异(P≥0.05)。结论:本研究未发现转基因棉籽对实验动物有亚慢性毒性。

Objective：To monitor the effects of genetically modified cottonseed on nutritional status,physiological and biochemical sub-chr-onic index in rats.Methods：A total of 140 six to eight-week-old SPF SD rats（male and female,half） were randomly divided into 7 groups,continuously feeding the forage containing 5%,2.5% and 1.25% normal cottonseed and transgenic cottonseed as well as basal forage for 30 days,and then measuring indicators of body weight,food efficiency,blood routine and blood biochemical parameters.Results：All the animals grow well and there is no poisoning and dead phenomenon during experimental time.Indicators between experimental and control group show no significant difference（P≥0.05）.Conclusions：The study did not find genetically modified cotton seeds has sub-chronic toxicity in experimental animals.