双环醇片治疗慢性肝炎高转氨酶血症的疗效观察

Observation on the effects of Bicyclol on high aminotransferase of chronin hepatitis

目的:观察双环醇片治疗慢性肝炎高转氨酶血症的临床疗效。方法:选择住院或门诊慢性肝炎高转氨酶血症患者280例,随机分为治疗组和对照组,治疗组141例,对照组139例。治疗组在常规保肝治疗的基础上加用双环醇片25m每日3次口服,对照组在常规保肝治疗的基础上加用甘利欣胶囊150mg每日3次口服。疗程均为4周。治疗前后每周详细记录患者症状、体征、肝功能、肾功能、电解质、及血尿常规,同时记录治疗过程中的不良反应及停药后随访3个月。结果:两组均有显著疗效,肝功能生化指标与治疗前相比有显著性差异(治疗组P<0.01,对照组P<0.05),治疗组明显优于对照组(P<0.05),且治疗组出现的不良反应明显少于对照组。结论:双环醇片治疗慢性肝炎高转氨酶血症疗效好,不良反应较少,值得临床推广。

Objective：To observe the clinical effect of Bicyclol on high aminotransferase of chronic hepatitis.Methods：In-patient or out-patient hospital chronic hepatitis patients with hyperlipidemia high aminotransferase 280 cases were randomly divided into treatment and control groups,the treatment group 141 cases,139 cases of the control group.In the conventional treatment group on the basis of protective and treatment plus a daily Bicyclol 25mg tid po;the control group in the conventional treatment of liver protection on the basis of protective and treatment plus a daily glycyrrhizinate capsules 150mg tid po.Courses are four weeks.Detailed records of a week before and after treatment in patients with symptoms and signs,liver function,kidney function,electrolytes,and hematuria conventional,and treatment records in the process of adverse reactions and follow-up after stopping three months.Results：The two groups were significantly effect,biochemical indicators of liver function before treatment compared with a significant difference（treatment group P 0.01,control group P 0.05）,the treatment group was significantly better than the control group（P 0.05）,the treatment group and the adverse reaction was less than the control group.Conclusion：All kinds of chronic hepatitis high aminotransferase treated with the bicyclol not only has the safety,affirmative advantage in curative effect,but fewer adverse reactions,deserve the clinical expansion.