161例患者围手术期抗菌药物应用分析

Application of antibacterial drugs of 161 patients in perioperative period

目的了解我院围手术期抗菌药物应用情况,为临床合理应用抗菌药物提供依据。方法随机抽取我院2009年7～12月出院手术病例161例,依据《抗菌药物临床应用指导原则》,调查围手术期抗菌药物预防应用情况。结果调查期间,我院围手术期患者抗菌药物预防应用率为100%,涉及十大类共19个品种,排在前五位的分别是奥硝唑、头孢呋辛、头孢米诺、阿洛西林及甲硝唑抗菌药物联合应用率57.76%,Ⅰ类切口联合应用率47.92%。术前0.5～2h内开始应用抗菌药物的占57.14%。抗菌药物平均应用时间4.76d,最长达15d。结论我院围手术期抗菌药物预防应用率及联合应用率偏高,用药指征不明确,目的性和针对性不强,应用时间偏长,需进一步规范管理。

Objective To investigate the utilization of perioperative antibacterial agents in Fuxing Hospital,and provide references for rational use of drugs in clinic.Methods 161 cases of patients were sampled randomly from the operation cases from June to December,2009.The application of perioperative antibacterial agents was investigated according to Clinical Guidelines for Antibacterial Agents.Results The precautionary use of perioperative antibacterial drugs was 100%among the patients in our hospital,which involves 10 sorts and 19 varieties.The top five are ornidazole,cefuroxime,cefminox,azlocilin,metronidazole.The combined utilization rate of antibacterial agents was 57.76%.The combined utilization rate of typeⅠwas 47.92%.57.14 percent of the patients started to use antibacterial drugs on 0.5 to 2 h before operation,and the average course of antibacterial drugs utilization was 4.76 d,the longest course was 15 d.Conclusion The rate of perioperative antibacterial drugs utilization and combined utilization were higher.The medication indications were not clear and the application coures was too long which need further standardization management