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帕金森病模型大鼠内侧前额叶皮层中间神经元电活动的增强 被引量：1

Increase of neuronal activity of the GABAergic interneurons in mPFC in PD rat
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摘要 目的研究帕金森病(PD)模型大鼠内侧前额叶皮层(mPFC)中γ-氨基丁酸(GABA)能中间神经元放电频率和放电形式的变化。方法应用在体细胞外电生理学记录的方法观察6-羟多巴胺(6-OHDA)损毁大鼠黑质致密部(SNc)后,mPFC中间神经元自发电活动的变化。结果 PD模型大鼠中间神经元的放电频率显著降低(P<0.001),使其从(11.95±0.81)Hz降至(7.28±0.78)Hz,放电形式趋向爆发(P<0.01)。结论单侧黑质-纹状体通路损毁对内侧前额叶皮层中间神经元的电活动有显著影响。 Objective To study the neuronal activity of GABAergic interneurons in medial prefrontal cortex（mPFC） in PD rat.Methods The change of the spontaneous firing of GABAergic interneurons in mPFC after SNc lesioned by 6-OHDA was observed by extracellular recording in vivo.Results The firing rate of GABAergic interneurons in mPFC decreased significantly from（11.95±0.81） to（7.28±0.78） Hz（P0.001）,and the firing pattern of these neurons changed significantly towards a more bursting firing（P0.01）.Conclusions Neuronal activity of mPFC GABAergic interneurons is significantly increased in PD rat.
作者 王爽 高捷 苏兴利 郭玉芳 霍健 王湘
机构地区 西安医学院病理生理学教研室 西北大学经济管理学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第11期2016-2018,共3页 Chinese Journal of Gerontology
关键词 帕金森病 内侧前额叶皮层 中间神经元 电生理学 Parkinson′s disease mPFC GABAergic interneurons Electrophysiology
分类号 R338.2 [医药卫生—人体生理学]
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参考文献10

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同被引文献37

  • 1陆建明,周厚广.帕金森病大鼠模型的行为学及神经元形态学评价(英文)[J].中国临床康复,2004,8(16):3180-3182. 被引量：5
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中国老年学杂志
2011年 第11期

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