摘要
目的探讨家兔上矢状窦(SSS)中1/3及其回流静脉结扎后邻近脑组织病理结构的改变。方法家兔SSS中1/3及其回流静脉被结扎,结扎后不同时间取窦旁脑组织行组织学和超微结构观察。结果结扎后4h,HE染色显示窦旁脑组织水肿明显,可见神经元变性,表现为核固缩,部分细胞致密、深染,突起消失,血管周隙增宽,可见血管扩张;尼氏染色显示神经元胞体肿胀,染色较淡,形态不规则,细胞排列散乱;电镜下观察发现神经元及胶质细胞水肿,线粒体结构模糊、部分嵴丢失呈空泡变,内质网扩张,核膜模糊;结扎后8h损伤最严重,之后逐渐恢复,至90d基本恢复正常。结论家兔SSS中1/3及其回流静脉结扎后可引起窦旁脑组织结构改变,但随时间延长可逐渐恢复正常。
Objective To explore the effect of ligating the middle parts of the superior sagittal sinuses (SSS) and their backflow veins on the pathomorphology and ultrastructures of the parasagital sinus cerebral tissues.Methods The middle parts of SSS and their back flow veins were ligated in the rabbits.The changes in the parasagital sinus cerebral tissues pathomorphology and ultrastructure were observed respectively by light and electron microscopes at different time after the ligation.Results The neuronal degeneration,the nerve cells and glial cell edema,the fuzzy mitochondrial structures,endoplasmic reticula expansion and so on were found in the parasagittal sinus cerebral tissues 4 hours after the ligation of SSS and their back flow veins.The above-mentioned changes become most significant 8 hours after the ligation and gradurally improved along with the prolongation of time after the ligation.The return of the parasagittal sinus cerebral tissues to almost normal was observed 90 days after the ligation.Conclusion The changes in the pathomorphology and ultrastructures of the parasagittal sinus cerebral tissues can be produced by the ligating the middle part of SSS and their back flow veins,but they may gradually become normal along with prolongation of the time after the ligation in the rabbits.
出处
《中国临床神经外科杂志》
2011年第5期293-295,共3页
Chinese Journal of Clinical Neurosurgery
关键词
家兔
上矢状窦
结扎
病理结构
Rabbits
Superior sagittal sinus
Ligation
Pathomorphology
Ultrastructure