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8q24染色体rs1447295A/C多态性与亚洲人群前列腺癌发病风险的Meta分析 被引量：2

Meta-analysis of Association of 8q24 rs1447295A/C Polymorphism and Risk of Prostate Cancer in Asian Men
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摘要 目的运用Meta分析的方法探讨8q24染色体rs1447295A/C多态性与亚洲人群前列腺癌发病风险的关系。方法检索在2009年底前在PubMed及中国期刊全文数据库发表的中英文文献。用RevMan4.2软件进行荟萃分析,评估异质性和发表偏倚。结果 4篇文献共3组不同种族人群纳入分析,前列腺癌组1 391例,对照组1 274例。前列腺癌组和对照组rs1447295A/C多态性现象中AA＋CA基因型频率与常见的纯合子CC基因型频率的合并比值比（OR）值为1.50,95%可信区间值为1.28~1.77,Z=4.92,P〈0.00001。结论 8q24染色体rs1447295A/C多态性与亚洲人群前列腺癌发病风险显著相关。 Objective To investigate the association of the rs1447295 locus polymorphism in the 8q24 chromosome and the risk of prostate cancer by means of Meta-analysis.Methods An electric search was performed in PubMed and CNKI database at the end of Dec 2009.All analyses were conducted with Review Manager Version 4.2 software.Results 4 literatures with 3 different ethnic groups were studied,totally including the PCa（Prostate Cancer） group（1 391 cases） and the normal control（1 274 cases）.The summary OR for studies with frequency of AA＋CA genotype at rs1447295 locus in the 8q24 was 1.50（95%CI： 1.28~1.77,Z=4.92,P0.00001）.Conclusion The meta-analysis suggests that the polymorphism at the rs1447295 locus of 8q24 might be a genetic risky factor for prostate cancer in Asian men.
作者 杨震宇 张旭 盛畅
机构地区 上海市浦东新区人民医院泌尿外科
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2011年第6期706-708,共3页 Cancer Research on Prevention and Treatment
关键词 前列腺癌 8q24 多态性 META分析 Prostatic Neoplasms 8q24 Polymorphism Meta-analysis
分类号 R737.25 [医药卫生—肿瘤]
  • 相关文献

参考文献14

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  • 10Robbins C, Torres JB, Hooker S, et al. Confirmation study of prostate cancer risk variants at 8q24 in African Americans i- dentifies a novel risk factor[J]. Genome Res, 2007, 17 (12) : 1717-1722.

二级参考文献22

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共引文献15

同被引文献32

  • 1王素萍,李泂.不饮酒和中度饮酒者心血管风险因素和混淆因子[J].国外医学（医学地理分册）,2006,27(2):86-87. 被引量：1
  • 2Parkin DM,Bray F,Ferlay J. Global cancer statistics[J].CA:A Cancer Journal for Clinicians,2005,(02):74-108.
  • 3Crawford ED. Epidemiology of prostate cancer[J].Urology,2003,(6Suppl1):3-12.
  • 4Amundadottir LT,Sulem P,Gudmundsson J. A common vari ant associated with prostate cancer in European and African popula tions[J].Nature Genetics,2006,(06):652-658.
  • 5Lichtenstein P,Holm NV,Verkasalo PK. Enviromental and heritable factors in the causation of cancer-Analyses of cohorts of twins from Sweden,Denmark,and Finland[J].New England Journal of Medicine,2000,(02):78-85.
  • 6Freedman ML,Haiman CA,Patterson N. Admixture map ping indentifies 8q24 as a prostate cancer locus in African-Ameri can men[J].Proceedings of the National Academy of Sciences(USA),2006,(38):14068-14073.
  • 7Wang L,McDonnel SK,Slusser JP. Two common chromo some 8q24 variants are associated with increased risk for prostate cancer[J].Cancer Research,2007,(07):2944-2950.
  • 8Gudmundsson J,Sluem P,Manolescu A. Genome-wide asso ciation study identifies a second prostate cancer susceptibility vari ant at 8q24[J].Nature Genetics,2007,(05):631-637.
  • 9Haiman CA,Patterson N,Freedman ML. Multiple regions within 8q24 independently affect risk for prostate cancer[J].Nature Genetics,2007,(05):638-644.
  • 10Robbins C,Torres JB,Hooker S. Confirmation study of pros tate cancer risk variants at 8q24 in African Americans identifies a novel risk factor[J].Genome Research,2007,(12):1717-1722.

引证文献2

二级引证文献2

肿瘤防治研究
2011年 第6期

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