新型芳烷酮哌嗪类衍生物YX0611-1对坐骨神经慢性压迫损伤大鼠的镇痛作用

Analgesic effect of novel aralkyl-ketone piperazine derivatives YX0611-1 on chronic constriction injury of the sciatic nerve rats

目的研究化合物YX0611-1对神经病理性疼痛大鼠的镇痛作用。方法建立CCI模型,采用Electronic von Frey法和热辐射法分别测定大鼠机械刺激缩足反射痛阈值(MWT)和热刺激缩足反射潜伏期(TWL)。结果 YX0611-1160 mg.kg-1组和80 mg.kg-1组单次给药均能明显提高大鼠的机械刺激阈值,延长大鼠热刺激潜伏期;YX0611-1 160mg.kg-1组多次给药能明显提高大鼠机械刺激阈值,延长大鼠热刺激潜伏期;YX0611-1 80 mg.kg-1组多次给药能明显提高大鼠的热刺激潜伏期。结论化合物YX0611-1对神经病理性疼痛大鼠有镇痛作用。

Aim To explore the anti-nociceptive effect of compound YX0611-1 in rats with a sciatic nerve chronic constriction injury （CCI）. Methods CCI model was performed as four ligatures placed around the fight sciatic nerve and tied without obstructing the blood supply of the nerve. Thermal withdrawal latency （TWL） and mechanical withdrawal threshold（MWT） of rats were determined by Hargreaves thermal radiation apparatus and electronic yon Frey＇s method of microfilament, respectively. Results YX0611-1 significantly reversed the reduction of mechanical and thermal by-peralgesia thresholds at doses of 80 mg·kg^-1 and 160 mg·kg^-1 after single gavage. Similar with the results of single gavage, the mechanical and thermal thresholds were also significantly enhanced at both doses after consecutive gavages, with the exception that YX0611-1 had no effect on mechanical threshold at 80 mg·kg^-l. Conclusion In rat with neuropathic pain,compound YX0611-1 exerts analgesic effect.