米非司酮配伍米索前列醇不同给药方式用于终止孕12-18周妊娠的临床观察

Mifepristone and Misoprostol for Termination of Pregnancy in Different Drμg Delivery 12～18 weeks pregnancy Clinical Observation

目的:探讨米非司酮配伍米索前列醇不同给药方式在孕12～18周引产中的疗效。方法:将61例孕12～18周具有中期妊娠引产指征的孕妇分为A组(31例)和B组(30例),两组米非司酮均按50 mg Q 12 h服用,共服3次,总量150 mg,服药前后2 h均空腹,于末次服完米非司酮后间隔1 h分别采取:A组顿服米索前列醇600μg;B组阴道一次性放置米索前列醇600μg,对两组引产效果进行回顾性分析。结果:米非司酮配伍米索前列醇用于中期妊娠引产疗效满意,不同给药途径引产效果具有统计学意义(P<0.05)。结论:口服米非司酮50 mg,Q 12 h,共三次并配伍米索前列醇600μg一次性阴道给药用于孕12～18周中期妊娠引产疗效安全可靠,值得临床推广、应用。

Objective：To study the efficiacy about Mifepristone and Misoprostol applied different dose and approaches to terminate 12~18 weeks gestation. Methods：Totally 61 cases of mid-trimester pregnancy after 12~18 weeks gestation were divided into A group（31 cases） and B group（30 cases）,the two groups also took mifepristone 50 mg Q12 h three times,the total dosage reached 150 mg,all subjects kept fasting for two hours before and after taking medicate,A group draμght and B group disposable vaginal dosage of misoprostol both are 600 μg 1 hour after the last mifepristone taking,and then the induced labors of two groups were analyzed retrospectively. Results：The satisfactory efficiacy was abtained by using Mifepristone and Misoprostol in mid-trimester pregnancy.There was statistically significant differences between two type of medication usage（P0.05）. Conclusions：Mifepristone 50 mg Q12 h three times combined disposable vaginal dosage of misoprostol 600 μg is a safe and reliable way for treating mid-trimester pregnancy after 12~18 weeks gestation.It deserves the clinical expansion and application.