mTOR、VEGF的表达与脑膜瘤病理分级的关系

Relationship between expressions of mammalian target of rapamycin and vascular endothelial growth factor and pathological grading of meningiomas

目的探讨哺乳动物雷帕霉素靶蛋白（mTOR）、血管内皮生长因子（VEGF）在脑膜瘤组织的表达及其与脑膜瘤病理级别之间的关系。方法取中山大学第一附属医院神经外科自1995年1月至2010年8月手术切除的脑膜瘤标本76例，其中Ⅰ级40例，Ⅱ级24例，Ⅲ级12例。采用免疫组化SABC法检测mTOR、VEGF在脑膜瘤组织中的表达。结果mTOR、VEGF阳性蛋白主要位于肿瘤细胞的胞浆中，为浅黄色至深黄色颗粒样物质。Ⅰ、Ⅱ、Ⅲ级脑膜瘤mTOR、VEGF的表达不同，差异均有统计学意义（P〈0．05）；脑膜瘤mTOR、VEGF蛋白的表达呈正相关关系（r=0．440，P=0．000）。结论mTOR、VEGF的表达与脑膜瘤的病理级别有关。

Objective To investigate the relationship between expressions of mammalian target ofrapamycin （mTOR） and vascular endothelial growth factor （VEGF） and pathological grading of meningiomas. Methods Seventy-six specimens of meningiomas, performed resection in our hospital from January 1995 to August 2010, were chosen, in which, 40 were of WHO grade I, 24 of WHO grade II, and 12 of WHO grade III. The expressions ofmTOR and VEGF were immunohistochemically studied with SABC method. Results The protein expressions of roTOR and VEGF mainly located in cytoplasm of meningioma cells, and these proteins were granular materials colored from pale yellow to dark yellow. The expressions of mTOR and VEGF were significantly different among meningiomas of grade I, II and III （P〈0.05）; the expressions of roTOR and VEGF had a positive correlation （r=0.440, P=0.000）. Conclusion The expressions of mTOR and VEGF are positively correlated with the tumor grades.