东北地区血培养病原菌分布及耐药性的临床分析

Distribution and Drug Ristance Analysis of Bacteria in Blood Culture of North-east China

目的：我国东北血培养中病原菌分布及其耐药性。方法：采用Bactec 9120血培养仪及凤凰-100全自动细菌鉴定药敏系统对门诊的血培养标本进行病原菌培养鉴定及药敏试验。结果：2008-10-2009-12血培养共分离菌372株,其中革兰阴性菌204株（66.45%）,革兰阳性菌125株（33.60%）,真菌43株（11.56%）。革兰阴性菌以肠杆菌科细菌为主（61.27%,125/204）;革兰阳性菌以表皮葡萄球菌属为主（22.4%,28/125）;真菌以白色念珠菌属为主（27.91%,12/43）。大多数病原菌的分离鉴定时间在3 d以内,约32株/9.8%的样本鉴定时间大于72 h。而革兰阴性菌主要对庆大霉素和复方新诺明产生耐药,革兰阳性菌主要对红霉素和庆大霉素产生耐药。结论：本地区血培养阳性结果中条件致病菌所占比例较高,存在一定程度的耐药性,具有较为明显的区域特征。

Objective：To investigate the ditribution and drug resistance of pathogenic bacteria isolated from blood culture in Nouth-eastern China during 2005-2007.Methods：Take Bactec 9120,all-auto blood culture instrument for blood sample,and Phoenix 100 to make drug senstitive test for the postive sample.Results：372 strains had been isolated in our hospital,includied Graim-negetive bacterial,Gram-postive bacterial,and fungi,the number of each kinds were 204（66.45%）,125（33.60%）,and 43（11.56%）respectively.Gram-negative rods were the predominant bacteria which caused sepsicemia.Most bacteria were isolated and detected less than 3 days,while the time for 32 strains/9.8% was more than 72h.Gentamicin and Trimethoprim/ Sulfamethoxazole were the most resistance drug to Gram-negetive bacteria,and Erythromycin,Gentamicin were the most resistance drug to Gram-postive ones.Conclusions：The stains isolated have good charaction related the regine.And the amount of drug resistance is much less than other hospitals.