氯沙坦对自发性高血压大鼠血管紧张素Ⅱ及炎症因子的影响

Effects of losartan on serum angiotensin Ⅱ and inflammatory cytokines in spontaneously hypertensive rat

目的观察血管紧张素Ⅱ(AngⅡ)的AT-1型受体阻断剂氯沙坦对自发性高血压大鼠(SHR)血清AngⅡ及炎症因子水平的影响。方法应用ELISA试剂盒检测SHR(n=12)和血压正常大鼠(WKY)(n=6)血清中AngⅡ的水平及炎症因子IL-1β、IL-6和高敏C反应蛋白(hsCRP)的浓度。结果 SHR血清中AngⅡ、IL-1β、IL-6及hsCRP水平明显升高,与WKY的相应指标比较差异均具有统计学意义(P值均<0.05)。氯沙坦在降低SHR血压的同时可以明显地降低其血清中AngⅡ、IL-1β、IL-6及hsCRP的水平,与用药前的相应指标比较差异均具有统计学意义(P值均<0.05)。结论氯沙坦可以降低SHR血清的AngⅡ及炎症因子IL-1β、IL-6和hsCRP的水平,这可能是氯沙坦的降压机制之一。

Objective To study the effects of losartan on the level of AngⅡ and inflamatory cytokines in spontaneously hypertensive rat（SHR）.Methods Serum concentrations of Ang II and inflammatory cytokines,including IL-1β,IL-6 and hsCRP were quantitatively analyzed in both SHR group（n=12） and WKY group（n=6）.Results The serum levels of Ang II,IL-1β,IL-6 and hsCRP were significantly elevated in SHR group（P0.05 vs.WKY group）.Both the blood pressure and the levels of these proteins were significantly decreased after treatment with losartan（P0.05）.Conclusion Losartan may lower the blood pressure through lowering the serum levels of Ang II,inflammatory cytokines（IL-1β,IL-6）,and hsCRP in SHR.