摘要
目的探讨多发性硬化症(multiple sclerosis,MS)患者血清中可溶性白细胞介素2受体(sIL-2R)水平的变化及临床意义。方法将21例MS患者按病情分为2组,MS急性复发组(n=15例)和MS缓解组(6例)。另选健康体检者(n=25)为对照组。采用双抗体夹心ELISA法检测3组血清sIL-2R水平的变化。结果 MS急性复发组和MS缓解组血清中sIL-2R水平均显著高于对照组(均P<0.01);MS急性复发组sIL-2R水平高于MS缓解组(P<0.05)。重型MS急性复发者SIL-2R水平高于轻型MS急性复发者(P<0.05)。结论检测sIL-2R水平的变化可用于评估机体免疫状态和作为MS患者病情严重程度的标志。
Objective To explore the changes in serum soluble interleukin 2 receptor（sIL-2R） levels and the clinical significance in multiple sclerosis（MS） patients.Methods Twenty-one MS patients were divided into two groups：MS acute relapse group（15 cases） and MS remission group（6 cases）.Furthermore,25 healthy control subjects were recruited.Serum sIL-2R levels were measured using a double antibody sandwich ELISA.Results Serum sIL-2R levels in MS acute relapse group and MS remission group were significantly higher than those in control group（all P〈0.01）,and the levels in MS acute relapse group were obviously higher than those in MS remission group（P〈0.05）.Severe acute relapse MS patients had higher sIL-2R levels than mild acute relapse MS patients（P〈0.05）.Conclusion Detection of changes in serum sIL-2R levels can be used to evaluate the patient＇s immune status and the severity of MS.
出处
《实用临床医学（江西）》
CAS
2011年第3期1-2,5,共3页
Practical Clinical Medicine
