对氨基水杨酸异烟肼联合左氧氟沙星、丙硫异烟胺治疗复治结核临床疗效观察

Clinical analysis of using para-aminosalicylic acid,levofloxacin and prothionamide to cure retreated pulmonary tuberculosis

目的观察复治肺结核患者采用2PaVPtAK(Sm)/16PaVPt方案治疗的疗效。方法 2006年1月～2009年12月住院的57例复治涂阳肺结核病人采用2PaVPtAK(Sm)/16PaVPt方案治疗,疗程中第0、2、6、12月、18月摄胸片、痰抗酸杆菌检查。结果 57例中52例完成疗程,结束时痰菌阴转率82.7%,肝功异常率9.62%。2例因副反应停药,3例因治疗失败改个体化方案。结论对复治肺结核患者采用2PaVPtAK(Sm)/16PaVPt方案治疗的效果满意,药物副反应小,该治疗方案值得临床推广。

Objective To observe and evaluate the treatment effect of retreated pulmonary tuberculosis cases by using 2PaVPtAK（Sm）/16PaVPt regimen.Methods 57 cases of retreated pulmonary tuberculosis were treated with 2PaVPtAK（Sm）/16PaVPt regimen from 2006 to 2009.The patients were examined with sputum smear and liver function,X-ray in the 0、2 nd、6 th、12 nd、18 th month.Reasults 52 cases finished the trearnent course.Among them,the sputum negative conversion rate was 82.7% amd 9.62% had abnormal liver function.2 cases stoped treatment due to side effects.3 cases changed their regimen due to therapeutic failure.Conclusion It is effective to treat retreated pulmonary tuberculosis cases with 2PaVPtAK（Sm）/16PaVPt regimen which deserves the clinical expansion.