NSCLC患者血清EGFR、VEGFA、VEGFR-2术前后变化及意义

Perioperative changes of serum levels of EGFR,VEGFA and VEGFR-2 in non-small cell lung cancer patients and the correlation between them

目的探讨NSCLC患者手术前后血清中EGFR、VEGFA、VEGFR-2的变化及三者之间的关系。方法用ELISA方法检测38例NSCLC患者手术前后血清中EGFR、VEGFA、VEGFR-2的水平。结果 1.术前血清EGFR、VEGF-A、VEGFR-2水平与NSCLC患者的临床病理特征无相关性(P>0.05)。2.术后一天血清EGFR、VEGF-A、VEGFR-2水平高于术前水平。3.术前EGFR血清水平与VEGFR-2呈正相关,与VEGFA无相关性;术后EGFR水平与VEGFA、VEGFR-2之间均无相关性。结论 NSCLC患者术前血清EGFR、VEGF-A、VEGFR-2水平不能成为临床病理特征的分子标志。术前、后EGFR、VEGF-A、VEGFR-2的表达受不同途径的调节。

Objective To explore the perioperative changes of serum levels of EGFR,VEGFA and VEGFR-2 in patients with non-small cell lung cancer（NSCLC） and the correlation in all the three.Methods The perioperative serum concentrations of EGFR,VEGFA and V EGFR-2 were detected in 38 patients with NSCLC by ELISA method.Results 1.The preoperative serum concentrations of EGFR,VEGFA and VEGFR-2 in NSCLC（P〉0.05） had no correlations with patients′ clinicopathological features.2.The postoperative serum concentrations of EGFR,VEGFA and VEGFR-2 were higher than preoperative serum concentrations.3.The preoperative serum concentration of EGFR had a positive correlation with serum V EGFR-2 concentration,but no correlation with VEGFA concentration in NSCLC patients;The postoperative serum concentration of EGFR had no correlation with VFGFA or VEGFR-2.Conclusion The preoperative serum concentrations of EGFR,VEGFA and VEGFR-2 can not be looked as a molecular marker of patients′ clinicopathological features.The pre and post operative expressions of EGFR,VEGFA and VEGFR-2 maybe controlled by diffenrent pathways.