澳洲茄胺盐酸盐对小鼠肝癌H22抑制作用研究

Inhibitory Effects of Solasodine Hydrochloride on Liver Cancer H22 in Mice

目的研究观察澳洲茄胺盐酸盐对移植性实体型肿瘤小鼠肝癌H22的瘤重抑制率.方法本项研究采用肿瘤细胞悬液接种法制备小鼠移植性实体型肿瘤H22动物模型.腹腔注射给药,连续10 d.给药结束后,解剖小鼠,取瘤称质量,进行统计学处理及分析,观察药物作用,连续3次重复实验.结果经过研究发现：澳洲茄胺盐酸盐对移植性实体型小鼠肝癌H22抑制实验3次重复实验证实,在药物倍数剂量设置下,44 mg/kg剂量组与盐水对照组比较,有显著性差异;44 mg/kg剂量组瘤质量抑制率在55.1%～73.7%之间,平均抑瘤率为62.3%,P〈0.01.结论通过连续3次重复实验,澳洲茄胺盐酸盐对小鼠移植性实体型肿瘤肝癌H22有明显的抑制作用.

Objective To observe the inhibitory rate of solasodine hydrochloride on the tumor weight of liver cancer H22,a transplanted solid tumor in mice.Method The transplanted solid tumor H22 mouse model was prepared by using a tumor cell suspension transplantation.The drug was administered in intraperitoneal injection for 10 days successively.After the administration,the mice were sacrificed,the tumors were removed and weighed,and the data were processed and analyzed statistically to investigate effects of the drug.The experiment was repeated three times.Results The inhibitory effects of solasodine hydrochloride at the dose of 44 mg/kg on transplanted solid liver cancer H22 were significant compared with those of the saline control group,and the inhibitory rates were in the range of 55.1%~73.7% with the average of 62.3%（P0.01）.Conclusion The data from three repeated experiments indicate that solasodine hydrochloride could produce a significant inhibitory effect on the transplanted solid liver cancer H22 in mice.