出血性脑卒中患者血管内皮祖细胞与相关危险因素的关系

Relationship between Endothelial Progenitor Cells and Risk Factors for Primary Intracerebral Hemorrhage

目的探讨血管内皮祖细胞(endothelial progenitor cells,EPCs)与出血性脑卒中危险因素的关系及临床意义。方法对75例不同时期的原发性脑出血卒中患者(急性期38例、稳定期37例)进行危险因素分析,以CD133/KDR+作为EPCs标记物,用流式细胞仪检测患者的CD133/KDR+双标记细胞数量,并与40例健康对照组循环EPCs水平进行比较。结果外周循环EPCs数量与高血压、高血糖、高血脂呈负相关(P<0.05或P<0.01);高血压、高血糖、高血脂、吸烟、饮酒能影响患者循环EPCs的水平(均P<0.05),而脑卒中家族史对循环EPCs水平无明显影响(P>0.05)。脑出血卒中患者循环EPCs水平明显低于对照组(P<0.05)。结论循环EPCs水平与脑出血危险因素负相关,可作为出血性脑卒中患者脑血管危险度的标志。

Objective To investigate the relationship between endothelial progenitors cells（EPCs） and risk factors for primary intracerebral haemorrhage.Methods Seventy-five patients with primary intracerebral hemorrhage（38 patients with acute,37 patients with stable）were enrolled to assess the risk factors.The number of circulating EPCs in these patients was measured as CD133/KDR＋ double positive cells using flow cytometry and was compared with that in 40 healthy controls.Results The number of circulating EPCs was inversely correlated with hypertension,hyperglycemia and hyperlipemia（P0.05 or P0.01）.No significant correlation existed between the history of stroke and levels of circulating EPCs（P0.05）.Hypertension,hyperglycemia,hyperlipidemia,smoking,drinking can affect the level of patients with circulating EPCs（all P0.05）.The levels of EPCs in patients with intracerebral hemorrhage were significantly lower than those in healthy controls（P0.05）.Conclusion The levels of circulating EPCs were negatively correlated with risk factors for intracerebral hemorrhage,and can be considered as a predictor of cerebrovascular risk in patients with primary intracerebral hemorrhage.