血清白介素-6在诊断肝细胞肝癌中的临床价值研究

Clinical Value of Serum Interleukin-6 in Diagnosing Primary Hepatocellular Carcinoma

目的:探索血清白介素-6(IL-6)在原发性肝细胞肝癌(HCC)诊断中的临床价值。方法:采用酶联免疫法(ELISA法)和电化学发光法分别测定30例原发性肝细胞肝癌患者、30例肝良性疾病患者血清白介素-6和甲胎蛋白(AFP)水平,并与30例正常对照组进行比较。结果:原发性肝细胞肝癌组患者血清IL-6水平(25.99±18.57 ng/L)及AFP水平(441.40±351.75μg/L)明显高于肝良性病组IL-6(9.09±7.44 ng/L)及AFP水平(86.86±58.64μg/L)和正常对照组IL-6(1.43±1.00 ng/L)及AFP水平(7.92±4.88μg/L),差异有统计学意义(p<0.05)。血清IL-6诊断原发性肝细胞肝癌的敏感性、特异性分别为83%、81%,而AFP的敏感性和特异性分别为63%、98%。二者联合检测时的敏感性、特异性则分别为90%,82%。结论:血清IL-6在原发性肝细胞肝癌的检测中敏感性明显高于AFP。若两项指标联合检测,可显著提高原发性肝细胞肝癌阳性检出率,有助于防止原发性肝细胞肝癌的漏诊。

Objective： To investigate the clinical value of serum interleukin-6（IL-6） in diagnosing primary hepatocellular carcinoma.Methods：Serum IL-6,AFP was respectively measured by enzyme linked immunosorbent assay and chemiluminessant immunoassay in 30 patients with primary hepatocellular carcinoma,30 patients with benign liver disease and 30 normal subjects.Results：Serum IL-6,AFP levels were significantly increased in primary hepatocellular carcinoma（p0.05）.For diagnosing primary hepatocellular carcinoma,the sensitivity and specificity of IL-6 and AFP were 83%,81% and 63%,98%,respectively;while the sensitivity and specificity with two tests combination were 90% and 82%,respectively.Conclusion：The sensitivity of IL-6 is higher than that of AFP in diagnosing primary hepatocellular carcinoma.The combination tests can increase the positive detection rate,and contribute to diagnose primary hepatocellular carcinoma.