胰腺癌神经浸润及临床研究新进展

Research progress of neural invasion of pancreatic cancer

胰腺癌的特点是神经浸润非常高发（可高达90％～100％），这与其生存率不高有关。肿瘤细胞胰内、胰外神经浸润是胰腺癌神经变化的典型表现。胰外神经丛浸润增加可以促进胰内神经浸润的发生，从而造成疼痛。胰腺癌诊断率的显著增加与新发糖尿病的诊断有关，高血糖也有促进胰腺癌神经浸润的可能。控制高血糖和光基因技术可作为胰腺癌神经浸润的辅助治疗，并且可以利用光基因技术对胰腺癌的神经浸润进行监测。

The high occurrence of neural invasion in pancreatic carcinoma, which can be as much as 90%-100%, leads to the poor survival rate in patients. The classical pathology includes invasion of both the extrapancreatic and intrapancreatic neurons. Metastasis into the extrapancreatic plexus promotes invasion into the intrapancreatic neurons and therefore results in pain. An increased in the diagnosis of new-onset diabetes mellitus, on the other hand, correlates with an increase in pancreatic cancer. This implies that hyperglycemia may promote neural invasion of pancreatic carcinoma. Novel auxiliary therapy of pancreatic carcinoma with neural invasion includes controlling of blood sugar and optogenetics, a new genetic technology which can further be utilized for surveillance.