腹膜溶质高转运的腹膜透析患者预后的差异性分析

Different prognosis in patients of peritoneal dialysis with high peritoneal solute transport

分析202例腹膜透析患者透析初期腹膜溶质高转运与透析时合并症的关系以及对患者预后的影响.腹膜溶质高转运患者与其他溶质转运类型患者相比,透析前的合并症比例高,腹膜透析超滤量少,营养状况差,患者累积生存率更低（均P〈0.05或0.01）;腹膜溶质高转运患者中,有合并症者的累积生存率明显低于无合并症者（P=0.031）.提示腹膜溶质转运功能对患者预后的影响可能与透析时的合并症有关.

To investigate association between prognosis of patients of peritoneal dialysis with their initial high peritoneal solute transport and complications. Two hundred and two patients with end-stage renal disease who began peritoneal dialysis during September 1,2006 to September 1, 2008 at Peking University Third Hospital, Beijing were recruited in the study. They were undergone peritoneal equilibration test within six weeks after initiating peritoneal dialysis, and their types of peritoneal solute transport, complications,nutrition status and outcomes were all recorded until August 31,2010. Their survival rate was estimated by Kaplan-Meier method. Compare to those with other types of solute transport, patients with high peritoneal solute transport showed higher proportion of complications （ P 〈 0. 05 ） during dialysis, but less ultrafiltration function （ P 〈 0. 05 ）, worse nutrition status （ P 〈 0. 05 ） and lower cumulative survival rate （ P 〈 0. 01 ）.Among patients with high peritoneal solute transport, cumulative survival rate in those with complication was lower than those without it （ P = 0. 031 ）. Prognosis of patients with high peritoneal solute transport possibly varies with their complications in dialysis.