子宫内膜癌组织中c-erbB-2及ki-67表达的临床意义

Expressions and Clinical Signifcancce of c-erbB-2 and ki-67 in Endometrial Carcinoma

目的探讨c-erbB-2、ki-67在子宫内膜癌中的表达及与子宫内膜癌发生、发展中的关系,为临床诊断和治疗提供依据。方法应用免疫组织化学SP法检测50例子宫内膜癌、45子宫内膜非典型增生及20正常子宫内膜组织中cerbB-2及ki-67的表达。结果在正常子宫内膜、子宫内膜不典型增生及子宫内膜癌中cerbB-2的阳性表达率分别为0、40.0%和68.0%,3组比较,差异有统计学意义(P<0.01)。Ki-67阳性表达率比较,子宫内膜癌中(72.0%)明显高于不典型增生子宫内膜(37.8%)、正常子宫内膜组织(35.0%)(均P<0.05)。cerbB-2、ki-67表达均与临床分期、肿瘤细胞组织学分级、浸润肌层深度密切相关(均P<0.05),但cerbB-2与淋巴结转移与否无关(P>0.05),ki-67表达与淋巴结有无转移有关(P<0.05)。结论 cerbB-2、ki-67的阳性表达对子宫内膜癌的发生、发展可能有促进作用,二者联合检测对早期诊断子宫内膜癌及判断预后有重要作用。

Objective To explore the expressions of c-erbB-2 and ki-67 in endometrial carcinoma and the relationship of the c-erbB-2,ki-67 and the development of endometrial carcinoma,and to provide the basis for the diagnosis and treatment.Methods 50 cases of endometrial carcinoma,45 cases of atypical hyperplasia and 20 cases of normal endometrium were collected,of them,c-erbB-2,ki-67 were detected by immunohistochemical method（SP）.Results The positive expression rate of cerbB-2 in the normal endometrium,atypical hyperplasia of endometrium and endometrial carcinoma was 0,40.0% and 68.0% respectively,there were significant differences in three tissues（P〈0.01）.The positive expression rate of ki-67 in the endometrial carcinoma（72.0%） was higher than that in the normal endometrium（35.0%）,atypical hyperplasia of endometrium（37.8%）（all P〈0.05）.The positive expression rate of cerbB-2,ki-67 were correlation with the clinical stage,histology grade of tumor cell and the deep of myometrial invasion（P〈0.05）,but cerbB-2 had no correlation with the lymph node metastasis（P〉0.05）,ki-67 had a correlation with the lymph node metastasis（P〈0.05）.Conclusion The positive expression of cerbB-2,ki-67 could promote the occurrence and development,it is important to detect cerbB-2,ki-67 for the judgement of the early diagnosis and prognosis of the endometrial carcinoma.