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免疫抑制剂寡聚脱氧核苷酸(ODN)的研究进展 被引量:1

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摘要 抑制性ODN的来源包括病毒基因组,哺乳动物染色体端粒,甲基化修饰的双链DNA人工合成的ODN,碱基替换的CG ODN及单核苷酸重复序列。目前已知的ODN多含有15~30个核苷酸,骨架结构大多经过了硫代修饰。它们具有拮抗Toll样受体的功能,从而抑制免疫细胞被内外源性Toll样受体(TLR)的配体激活。随着对抑制性ODN研究的增多,对其研究的热点集中在了应用其治疗TLR活化的相关疾病及自身免疫病。
作者 康海珍
出处 《中国医药指南》 2011年第18期225-226,共2页 Guide of China Medicine
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参考文献9

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同被引文献14

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