腹膜透析患者腹膜超滤衰竭的新靶点:腹膜血管的生成

A New Target of Peritoneal Ultrafiltration Failure in Peritoneal Dialysis Patients:Peritoneal Angiogenesis

目的:综述腹膜透析患者腹膜超滤衰竭的主要原因。方法:通过查阅文献,从目前对腹膜超滤衰竭的发生,腹膜结构和功能的改变,综述腹膜血管生成特征的研究进展。结果:多种原因可促进腹膜血管内皮生长因子(VEGF)表达、促进腹膜新生血管的增生,从而增加腹膜转运的有效滤过面积,减少超滤量,腹膜新生血管的生成是患者腹膜超滤衰竭的主要原因。结论:引起腹膜超滤衰竭发生的诸多原因及机制中,腹膜组织新生血管形成占主导地位,是腹膜超滤衰竭病因学的研究热点,多种方法可能可以干预新生血管的形成。

Objective： To analyze the major causes and tactics of ultrafiltration failure in long peritoneal dialysis patients. Methods： Through a large number of documents, we reviewed the characteristics of peritoneal angiogenesis research progress from the current points of incidence of peritoneal ultrafihration failure, and the change of peritoneal structure and function. Results： Various causes can stimulate the expression of VEGF in peritoneal membrane tissue, and promote the proliferation of new vascular, which result in increased effective peritoneal surface area of peritoneal membrane and reducd ultrafihration. Peritoneal angiogenesis was the main reason of peritoneal ultrafiltration failure. Conclusion： Peritoneal angiogenesis was the major reason of peritoneal ultrafiltration failure, which was also the research focus. There were a variety of methods to interfere the formation of new blood vessels.