新疆地区成年体检人群中慢性肾脏病患病率及相关危险因素调查

Prevalence and risk factors of chronic kidney disease in the adult population receiving healthy examination from Xinjiang

目的调查新疆地区成年体检人群慢性肾脏病（CKD）的患病情况及相关危险因素。方法回顾性分析2009年1月至2010年4月在新疆医科大学第一附属医院体榆中心所有年龄大于20周岁的人群体检资料，进行CKD患病率和危险因素调查分析。结果在资料完整的10025例成年体检者中，蛋白尿的患病率为4．86％（95％CI为4．44％-5．28％）；血尿的患病率为3．13％（95％CI为2．79％～3．47％）；肾小球滤过率下降的患病率为2．66％（95％CI为2．34％～2．98％）。该人群总CKD患病率为9．60％（95％CI为9．02％～10．18％）。多因素Logistic回归分析提示男性、高收缩压、肥胖、糖代谢异常、高三酰甘油血症与蛋白尿独立相关；女性、民族、高收缩压与血尿独立相关；性别、年龄增加10岁、肥胖、高脂血症、高尿酸血症与肾功能下降独立相关；与CKD总体独立相关的因素是性别、年龄增加10岁、高收缩乐、糖代谢异常、高脂血症和高尿酸血症。结论新疆地区成年体检人群CKD的患病率为9．60％，提示健康体柃人群CKD的患病率也很高，应引起重视。新疆地区CKD的疾病谱与国内及国外研究类似。

Objective To investigate the prevalence and risk factors of chronic kidney disease （CKD） in the adult population receiving healthy examination from Xinjiang. Methods A total of 10 025 subjects who were older than 20 years and received healthy examination in Health Center of the First Affiliated Hospital, Xinjiang Medical University, from January 2009 to April 2010 were enrolled. Results The prevalence of proteinuria was 4.86%（95%CI：4.44%-5.28%）, hematuria 3,13% （95% CI：2.79%-3.47%）, and reduced eGFR 2.66% （95% CI：2.34%-2.98%）. Approximately 9.60% （95%C1：9.02%-10.18%） of these subjects had at least one indicator of kidney damage. Albuminuria was independently associated with male, systolic blood pressure, BMI, glycmnetabolism abnormity, hypertriglyceridemia. Hematuria was independently associated with female, minority, aystolie blood pressure. Reduced eGFR was independently associated with female, age, obesity, hyperlipidemia, hyperuricemia. Age, gender, glycometabolism abnormity, systolic blood pressure, hyperuricemia and hyperlipidemia were independently correlated with CKD. Conclusions The prevalence of chronic kidney disease is 9.60% in the adult population receiving healthy examination, which is quite high and should be considered. The spectrum and correlated factors ofCKD in this population are similar to studies reported.