丝素蛋白在电纺丝法构建组织工程支架中的应用进展

Progress and prospect of electrospun silk fibroin in construction of tissue-engineering scaffold

丝素蛋白是天然高分子纤维蛋白,具有良好的物理和机械力学性能及生物相容性,因而在组织工程领域有着广阔的应用前景。文中对丝素蛋白的化学组成、分子结构特点、提取方法以及利用静电纺丝技术在组织工程化支架构建中的应用作了概述。总结了丝素蛋白在用于组织工程材料上的性能和优势以及在人工血管、皮肤、骨组织等工程化支架方面的应用情况,探讨了丝素蛋白支架对细胞在其上生长、增殖和功能的影响,同时对丝素蛋白在组织工程化食道支架及其他再生医学上的应用前景进行了展望。

Silk fibroin is a natural macromolecular fibroin.It has broad prospects in tissue engineering application due to its good physical and mechanical properties and good biocompatibility.This paper reviews its chemistry structure,property,the usage as matrix of tissue-engineering scaffold using electrospinning technology,and the influence on growth,proliferation and function of vascular endothelial cell,smooth muscle cell,keratinocyte and fibroblast.It also addresses the advantages and disadvantages of silk fibroin applied in tissue engineering study like artificial vascular,skin,bone stent etc.The potential applications on esophageal tissue engineering and regenerative medicine were discussed.