摘要
目的建立HPLC法,测定盐酸度洛西汀的有关物质。方法色谱柱为Inertsil CN-3(4.6 mm×250 mm,5μm),流动相为0.05 mol/L磷酸二氢钾溶液(用三乙胺调节pH值为6.0)-乙腈(30∶70),流速为1.0mL/min,检测波长为228 nm。结果盐酸度洛西汀与杂质能完全分离。结论本方法可准确、快速、简便地测定盐酸度洛西汀中的有关物质。
Objective To establish an HPLC method for determining related substances of duloxetine hydrochloride.Methods An Inertsil CN-3（4.6 mm×250 mm,5 μm）column was used with 0.05 mol/L potassium dihyduogen phosphate solution（adjusted to pH 6.0 with triethanolamine）and acetonitrile（30∶70）as the mobile phase,the flow rate was 1.0 mL/min,the detection wavelength was 228 nm.Results The related substances were separated from duloxetine hydrochloride.Conclusion The method is convenient,sensitive and accurate for determination of its related substance.
出处
《实用药物与临床》
CAS
2011年第3期234-235,共2页
Practical Pharmacy and Clinical Remedies
