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Cbl-b在T细胞免疫耐受和肿瘤免疫治疗中的作用 被引量：2

Role of Cbl-b in T cell immune tolerance and tumor immune therapy
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摘要 Cbl-b(casitas B-cell lineage lymphoma-b)为一种高度保守的RING家族E3泛素连接酶,是调节T细胞信号的关键因子,对维持外周T细胞免疫耐受至关重要。Cbl-b表达受转录因子、共刺激分子CD28、CTLA4及自身泛素化的调控。Cbl-b通过泛素化激活的受体、受体相关酪氨酸激酶和下游信号分子而参与淋巴细胞信号的负性调控,进而精密调节抗原受体信号和免疫反应。另外,Cbl-b在调控T细胞TGF-β信号转导通路中起着重要作用。Cbl-b的缺失能增强抗肿瘤免疫反应,打破自身免疫耐受。因此,深入研究Cbl-b在T细胞免疫耐受和肿瘤免疫治疗中的作用可为肿瘤免疫治疗提供新的靶点。
作者 曲晶磊 曲秀娟 刘云鹏
机构地区 中国医科大学附属第一医院肿瘤内科
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2011年第3期343-346,共4页 Chinese Journal of Cancer Biotherapy
基金 国家自然科学基金资助项目(No.30770993 No.31000607)~~
关键词 CBL-B 肿瘤 T细胞 免疫耐受
分类号 R730.51 [医药卫生—肿瘤] R392.1 [医药卫生—免疫学]
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参考文献27

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同被引文献31

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中国肿瘤生物治疗杂志
2011年 第3期

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