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水冷式单针射频热消融系统可消融范围测定的实验研究 被引量:2

Experimental study of a novel radiofrequency ablation system
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摘要 目的通过离体器官和活体动物实验,确定水冷式单针射频消融系统的功率、时间、消融范围的相关曲线,为实际应用提供理论依据。方法采用水冷式单针射频消融系统分别对新鲜牛肝脏、健康成年新西兰白兔的肝脏和肌肉组织实施射频消融处理,经多路测温系统实时采集消融区域的温度场数据,以50℃为温度区域边界确定实际达到的最大消融范围,并计算离体肝脏组织的比吸收率(SAR)。结果在100-130V治疗电压范围内,治疗过程平稳,阻抗无明显变化,最大单次消融直径达51mm。在140~170V治疗电压范围内,较短时间即可达到较大的消融范围,但之后阻抗开始上升,组织消融范围不再继续扩大。在180~200V电压范围内,几乎都出现快速的阻抗超标、射频治疗自动终止而不能正常完成射频消融。实际测得肝脏组织的SAR与理论值相符。病理学观察证实肝脏、肌肉组织发生了典型的凝固性坏死。结论该水冷式单针射频消融系统在实验过程中,功放、水冷、测温及控制部分均运行平稳,实际消融效果达到了设计要求和临床治疗的需要。 Objective To determine the power-time-ablation scope correlogram of a water-cooled single needle electrode radiofrequency (RF) ablation system and to establish a theoretical basis for its practical application. Methods RF ablations were performed using a water-cooled single needle electrode radiofrequency ablation system developed by the authors using fresh ox liver as well as liver and muscles of healthy adult New Zealand white rabbits. The temperature of the ablation area was monitored using a muhichannel thermometric system. The maximum ablation scope was determined by detecting the rim at which the temperature was no less than 50℃. The specific absorption rate (SAR) of the isolated liver tissue was calculated. Results In the treatment voltage range of 100-130V, the process was smooth and steady. No impedance variation was obvious. The maximum diameter of a single ablation was 51 cm. With the treatment voltage at 140-170 V, a larger ablation area could be reached in less time, but eventually the impedance began to increase while the ablation area was no longer expanded. When the treatment voltage reached the range of 180-200 V the impedance almost always increased rapidly out of limits, and the treatment system stopped automatically. The measured SAR value was consistent with the theoretical value. Pathology confirmed that both liver tissue and muscle tissue manifested typical coagulative necrosis. Conclusions The power amplifier, cooling, thermometric and control sections of the RF ablation system worked stably, and the practical ablation effect met the design and clinical treatment requirements.
出处 《中华物理医学与康复杂志》 CAS CSCD 北大核心 2011年第6期417-421,共5页 Chinese Journal of Physical Medicine and Rehabilitation
基金 上海市科委科技发展基金(08140902100),上海交大医工(理)交叉研究基金(YG2009MS13)
关键词 射频消融 新西兰白兔 消融范围 比吸收率 Radiofrequency ablation New Zealand white rabbits Ablation area Specific absorption rate
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参考文献6

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同被引文献19

  • 1杨焰,罗葆明,智慧.冷循环射频消融输出功率及作用时间与凝固灶大小的关系[J].中国组织工程研究与临床康复,2007,11(26):5106-5108. 被引量:13
  • 2梁超英,钱志余.人体组织传热及应用研究[J].生物医学工程研究,2007,26(2):212-215. 被引量:4
  • 3戴良图,杨晓玉.温度控制和功率控制射频消融治疗子宫肌瘤临床研究[J].中国妇产科临床杂志,2007,8(5):339-342. 被引量:6
  • 4Holmes D, Fish JM, Byrd IA, et al. Contact Sensing Pro- vides a Highly Accurate Means to Titrate Radiofrequency Ablation Lesion Depth[J]. Cardiovasc Electrophysiol,2010, 29(10): 1540-8167.
  • 5Wang Z, I Aarya, M Gueorguieva et al. Image-based 3D modeling and validation of radiofrequency interstitial tumor ablation using a tissue-mimicking breast phantom[J]. Inter- national Journal of Computer Assisted Radiology and Sur- gery,2012,1-8.
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  • 8HAEMMERICH D. Mathematical modeling of impedance controlled radiofrequency tumor ablation and exvivo valida- tion [C]. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Bue- nos Aires: 2010: 1605-1608.
  • 9KESHTKAR A, MESBAHI A, MEHNATI P. The effect of bladder volume ehanges on the measured electrical impedance of the urothelium [J]. Int J Biomed Eng Teehnol, 2008, 1 (3) .. 287-293.
  • 10徐晓菲,白景峰,陈亚珠.水冷式射频消融过程中水冷温度对热损伤的影响[J].北京生物医学工程,2008,27(4):393-395. 被引量:7

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