血清Apelin及对氧磷脂酶1与2型糖尿病患者动脉粥样硬化程度的关系

Study on the Relationship Between Serum Apelin,paraoxonase-1 and Degree of Atherosclerosis in Type 2 Diabetes Patients

目的观察2型糖尿病动脉粥样硬化患者血清Apelin、对氧磷脂酶1及丙二醛的变化。方法 2008年6月~2010年6月我院收治的2型糖尿病患者200例行颈动脉、下肢动脉彩色B超,其中无动脉粥样硬化者40例为非动脉硬化组,动脉粥样硬化的160例患者为动脉硬化组,根据动脉粥样硬化等级进一步分为4组：1级42例、2级39例、3级41例及4级38例。选择同期健康体检者40例为对照组。比较各组患者血清Apelin、对氧磷脂酶1及丙二醛的水平。结果动脉硬化1级与对照组比较,血清Apelin、对氧磷脂酶1及丙二醛均无明显变化（P〉0.05）;2级~4级血清Apelin和对氧磷脂酶1均明显低于对照组,丙二醛则高于对照组（P〈0.01）;2级~4级组间比较Apelin、对氧磷脂酶1及丙二醛均差异有显著性（P〈0.05）。结论血清Apelin、对氧磷脂酶1的降低是2型糖尿病患者动脉粥样硬化的预警因子。

Aim To observe the change of serum Apelin,PON1 and malondialdehyde（MDA） in arteriosclerosis with type II diabetes patients. Method Carotid artery and lower extremity artery ultrasonic doppler were performed on patients with type II diabetes from Jun 2008 to Jun.2010.40 non-atherosclerosis cases were divided into non-atherosclerosis group,while 160 cases with atherosclerosis were divided into atherosclerosis group.They were further divided into four groups according to their grade of atherosclerosis,42 cases of grade Ⅰ,39 of grade Ⅱ,41 of grade Ⅲ,and 38 of grade Ⅳ.40 health cases during the same period were chosen as control group.The level of serum Apelin,PON1 and MDA in each group were compared. Result Grade I group had no obvious change with control group in serum Apelin,PON1 and MDA（P0.05）;Apelin and PON1 in gade Ⅱ,grade Ⅲ and grade Ⅳ group were significantly lower than those in control group,and MDA was higher than control group（P0.01）;Apelin,PON1 and MDA in gade Ⅱ,grade Ⅲ and grade Ⅳ group had significant difference（P0.05）. Conclusion The decrease of Apelin and PON1 is the warning factor of atherosclerosis in type 2 diabetes patients.