甲胎蛋白的生物学功能

Biological functions of alphafetoprotein

甲胎蛋白(AFP)不仅是肝细胞癌诊断的重要标志物,还在肝癌细胞的生长、增殖及凋亡等过程中发挥着重要的生物学作用.除了胞外的配体结合和运输功能,以及作为生长调控因子刺激肿瘤细胞生长外,细胞内的AFP还可以通过和转录因子或一些关键蛋白之间发生相互作用而作为信号分子参与对下游基因的转录调控或对信号通路产生影响.这些为我们研究AFP在肿瘤的癌变及化疗中的影响机制提供了新的思路.

Alpha-fetoprotein（AFP） is a well-known biomarker for the diagnosis of hepatocellular carcinoma.Extracellular AFP can act as a carrier to transport a variety of ligands or as a growth regulator to control the growth of tumor cells,while intracellular AFP can bind to and interact with transcription factors or some key proteins and function as a signal molecule to regulate cell proliferation or apoptosis.This paper provides novel insights into the mechanisms underlying the role of AFP in carcinogenesis and tumor chemotherapy.