摘要
μ型阿片受体(mu opioid receptor,MOR)作为G蛋白偶联受体的成员之一,在疼痛传递、炎症过程、免疫调节等多种生理及病理反应中发挥重要作用.MOR在中枢和外周都有大量表达,在胃肠道中主要分布于肠道淋巴细胞、肠肌层及黏膜下神经元中,对肠道蠕动、分泌功能都有重要作用.一些动物实验和体外实验结果表明MOR的激动剂在治疗炎症性肠病(inflammatory bowel disease,IBD)方面具有重要的潜在价值,已经成为治疗IBD的一种新靶点.本文对MOR的功能及其与IBD的潜在联系进行了综述,为深入研究治疗IBD的新途径提供理论依据.
The mu opioid receptor（MOR）,a member of G protein-coupled receptors,plays a pleiotropic role in various physiological and pathological processes,such as pain,inflammation,and immune modulation.MOR is expressed abundantly in both central and peripheral tissues and plays a significant role in peristalsis and secre-tion.It has been documented that MOR agonists are potentially valuable agents for the treatment of inflammatory bowel disease（IBD）.This paper will explore the link between MOR and IBD,aiming at providing a theoretical basis for future development of new treatments for IBD.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第14期1489-1493,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金青年基金资助项目
No.30901057~~
