伴有自身免疫性疾病的慢性乙型肝炎患者的抗病毒治疗

Antiviral therapy in patients with concomitant chronic hepatitis B and autoimmune diseases

慢性乙型肝炎患者伴有自身免疫性疾病在临床上比较常见,大部分这类患者需要抗乙型肝炎病毒治疗.核苷(酸)类似物和干扰素等抗乙型肝炎病毒药物在治疗此类患者时各有优劣,收益与风险并存.因此,临床实践中应该充分评估患者伴发的自身免疫性疾病种类和严重程度,选择最合适的抗乙型肝炎病毒药物,避免造成医源性损伤.

Chronic hepatitis B with concomitant autoimmune diseases is clinically common,and most of these patients need antiviral treatment.Each type of anti-HBV agent,such as nucleos（t）ide analogues and interferon-α,has its own unique advantages and disadvantages.Before selecting optimal antiviral therapy,we should evaluate these patients adequately to avoid iatrogenic injuries.For example,which autoimmune disease is the patients suffering from？How serious is the disease？