36例三阴性乳腺癌的临床与病理分析

Clinical and pathological analysis of 36 cases of triple-negative breast cancer

目的 探讨三阴性乳腺癌的临床病理特点.方法 回顾性分析2006年5月-2010年7月经手术治疗的36例三阴性乳腺癌及同期非三阴性乳腺癌患者资料：发病年龄、肿物大小、病理分期、淋巴结转移情况及雄激素受体的表达,并进行分析比较.结果 三阴性乳腺癌组患者年龄较非三阴性乳腺癌组年轻（χ2=3.861,P〈0.05）;三阴性乳腺癌组淋巴结转移、TNM分期与非三阴性乳腺癌组比较差异有统计学意义（χ2分别为4.632、5.016,均P〈0.05）;三阴性乳腺癌组雄激素受体阳性表达率低于非三阴性乳腺癌组（χ2=42.960,P〈0.05）;三阴性乳腺癌组淋巴结转移率与肿瘤大小差异有统计学意义（χ2=6.076,P〈0.05）.结论 三阴性乳腺癌患者年龄较小,临床病理分期较高,淋巴结转移多见,雄激素受体阳性表达率较低,预后差.

Objective To investigate the clinical and pathological features of triple-negative breast cancer （TNBC）. Methods The data of 36 cases of TNBC and non-triple-negative breast cancer （non-TNBC） treated with operation from May 2006 to July 2010, including age of onset, size of tumor, pathological stage, metastasis of lymph node, and expression of androgen receptor （AR） were retrospectively analyzed and compared. Results The patients with TNBC were younger than those with non-TNBC （X2 = 3. 861, P 〈 0.05 ）, and the rate of positive expression of AR in TNBC group was lower than that in non-TNBC group （X2 = 42.960 ,P 〈 0.05 ）. The differences in lymph node metastasis and TNM stage were statistically significant between two groups （X2 = 4. 632,5. 016, P 〈 0.05 ）. The rate of lymph node metastasis and tumor size were significantly different between two groups （X2 = 6. 076,P 〈 0.05 ）. Conclusion TNBC group is featured as younger onset age, higher clinical and pathological stage, more metastasis of lymph node, lower rate of positive expression of AR and poorer prognosis.