联合检测血清指标在肝胆疾病诊断中的价值

Clinical value of combined detection of several serum items in the diagnosis of liver and gallbladder diseases

目的探讨腺苷脱氨酶(ADA)、α-L-岩藻糖苷酶(AFU)、丙氨酸氨基转移酶(ALT)、总胆汁酸(TBA)的检测在肝胆疾病中的诊断意义。方法使用SYNCHRON LX-20全自动生化分析仪检测150例肝胆疾病患者和40例健康人血清的各项指标,并对检测结果进行统计学分析。结果 4项指标在各组肝病中均有不同程度升高,ADA在急性肝炎、慢性活动性肝炎、慢性迁延性肝炎、肝硬化组中差异有统计学意义(P<0.05),而TBA在急性肝炎、肝硬化组中升高比慢性迁延性肝炎、慢性活动性肝炎组更明显(P<0.05),AFU在急性肝炎、肝硬化、肝癌组中均增高(P<0.05)。结论联合检测血清指标对肝胆疾病的诊断具有临床价值。

Objective To investigate the clinical value of adenosine deaminase（ADA）,α- fucosidase（AFU）,alanine aminotransferase（ALT） and total bile acid（TBA）in the diagnosis of liver and gallbladder diseases. Methods 150 cases of patients with liver and gallbladder diseases and 40 cases of healthy controls were enrolld and detected for serum levels of the mentioned items by using SYNCHRON LX-20 automatic biochemical analyzer. Then the deteeed results were statistically analyzed. Results The serum levels of the four indicators increased with variant digree in all disease groups. Serum ADA levels of patient groups with acute hepatitis, chronic active hepatitis, chronic persistent hepatitis,and hepatic cirrhosis were significantly different （P〈0.05）. Serum TBA levels of patient groups with acute hepatitis and hepatic cirrhosis were highr than of patients groups with chronic persistent hepatitis and chronic active hepatitis （P〈0. 05）. Serum level AFU of patient groups with acute hepatitis,liver cirrhosis and liver cancer increased significantly （P〈0.05）. Conclusion Combined detection of serum items could have certain clinical value in the diagnosis of liver and gall diseases.