丙型肝炎患者抗肝抗原自身抗体与病毒复制的相关性研究

Correlation of anti-liver antigen autoantibody and virus replication in patients with hepatitis C

目的研究丙型肝炎患者抗肝抗原自身抗体与HCV病毒复制的相关性。方法回顾性分析2009年9月至2010年9月的279例抗HCV阳性患者HCV RNA检测及抗肝抗原自身抗体谱检测结果,利用统计学方法研究HCV RNA与抗肝抗原自身抗体谱的相关性。结果 279例抗HCV阳性患者中,有162例(58.1%)患者HCV RNA阳性,其中抗线粒体抗体M2型(AMA-M2)阳性11例(6.8%)、抗可溶性肝抗原抗体(SLA)阳性16例(9.9%)、抗肝肾微粒体抗体(LKM-1)阳性29例(17.9%)、抗肝细胞溶质抗原1型(LC-1)阳性9例(5.6%);117例(41.9%)患者HCV RNA阴性,其中AMA-M2阳性3例(2.6%),SLA阳性3例(2.6%),LKM-1阳性15例(12.8%)、LC-1阳性4例(3.4%)。两者抗肝抗原抗体谱阳性率差异有统计学意义(χ2=92.8,P<0.05)。结论 HCV RNA阳性患者抗肝抗原自身抗体谱阳性率明显高于HCV RNA阴性患者。

Objective To study the correlatioin of anti liver antigen autoantibody and virus replication in patients with hepatitis C. Methods The correlation of HCV RNA and anti-liver antigen autoantibody were analyzed by the retrospective analysis of relative results of 279 patients with positive anti HCV during Sep 2009 and Sep 2010. Results In all patients,162 （58.1%） cases were HCV RNA positive,among which 11 （6.8%） cases were with type M2 anti mitochondrial antibody （AMA-M2）,16 （9.9%） with anti soluble liver antigen （SLA） antibody,29 （17.9%） with anti-liver kidney microsomal （LKM） antibody and 9 （5.6%） with anti-liver cytosolic antigen-1（LC-1） antibody, 117（41.9.%） cased were HCV RNA negative,among which 3 （2.6%） cases were with AMA M2,3 （2.6%） with anti-SLA antibody,15 （12.8^） with anti-LKM antibody and 4 （3.4%） with anti-LC-1 antibody. There was significant difference of positive rate （χ^2= 92.8,P〈0.05） between the two groups. Conclusion The positive rate of anti-liver antigen autoantibody in HCV RNA positive patients is significant higher than it in HCV RNA negative patients.