鼻用原位凝胶给药系统研究进展

Advances in Research on In Situ Gel for Nasal Drug Delivery System

原位凝胶是指高分子材料以溶液或半固体状态给药后,在给药部位对外界刺激(用药部位的温度、pH值、离子种类和浓度等变化)产生响应,发生分散状态或构象的可逆转化,形成的半固体或固体制剂。其分为温度、离子强度以及pH敏感等类型,并均能较好地用于鼻腔给药。鼻黏膜分布着丰富的血管,药物可直接进入体循环,有效避免肝的首过效应,提高药物的生物利用度。原位凝胶用于鼻腔给药系统具有较好的应用前景,值得深入开发研究。

In suit gel refers to that polymer materials dosed with solution or semisolid state, reacting to external stimuli such as the change of temperature, pH value, ion species and concentration etc, resulted in decentralized state or conformation conversed reversibly and formed solid or semisolid preparation.h divided into thermo-sensitive, ion-actived and pH-sensitive type ete, all of which can be well applied to nasal medication. Mucosal surfaces of nasal are rich in blood supply, providing the means for rapid drug transport to the systemic circulation, avoiding degradation by first-pass hepatic metabolism and improving the bioavailability of drugs. In situ gel for nasal drug delivery system has a good prospect, deserving in-depth development research.