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Siah2在肿瘤发生、发展过程中的作用 被引量：1

The function of Siah2 in cancer occurrence and development process
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摘要 肿瘤已经成为制约人类健康的第二大疾病,最新研究表明Siah2在肿瘤发生发展中起着至关重要的作用。本篇文章重点论述Siah2诱发肿瘤的机制,通过siah2/PHD/HIF-1α通路及siah2/SPRY2/Ras两条通路。除介绍各环节结构及生物特性,更阐明其间的相互作用及信号通路,为肿瘤治疗提供参考依据。 Cancer has become the second disease which restricts human health. A new research showed that Siah2 plays an important role in cancer process. This article stresses the mechanism that Siah2 induced cancer. Through siah2/PHD/HIF-la path and siah2/SPRY2/Ras path. Except introducing the structure and biological propertieseacb of each part, the interaction and signal pathway are the emphasis which offer the reference of treating cancer.
作者 李晓智 韩雪 李昊怡
机构地区 中国医科大学
出处 《中医临床研究》 2011年第11期119-120,共2页 Clinical Journal Of Chinese Medicine
关键词 Siah2 PHD HIF SPRY2 RAS 肿瘤 Siah2 PHD HIF SPRY2 Ras Cancer
分类号 R730.231 [医药卫生—肿瘤]
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参考文献16

  • 1Reed J C,Ely K R.Degrading liaisons:Siah structure revealed[J].Nat Struct Biol,2002,9(l):8-10.
  • 2Siah2 Regulates Stability of Prolyl-Hydroxylases,Controls HIF1 α Abundanc -e,and Modulates Physiological Responses to Hypoxia[J].
  • 3Forsythe J A,Jiang B H,Iyer N V,et al.Activation of vascular endothelial gro -wth factor gene transcription by hypoxia-inducible factor 1[J].Mol Cell Biol,1996,16(9):4604-4613.
  • 4Staller P,Sulitkova J,Lisztwan J,et al.Chemokine receptor CXCR4 downregul ated by von Hippel-Lindau tumour suppressor pVHL[J].Nature,2003,425(6955):307-311.
  • 5Epstein A C,Gleadle J M,McNeill LA,et al.C.elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxyl -ation|J].Cell,2001,107(1):43-54.
  • 6Nakayama K,Qi J,Ronai Z.The ubiquitin ligase Siah2 and the hypoxia respon -se[J].Mol Cancer Res,2009,7(4):443-451.
  • 7Normal pS3 function in primary cells deficient for Siah genes[J].
  • 8MacLeod R J,Hayes M,Pacheco I.Wnt5a secretion stimulated by the extracell -ular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells[J].Am J Physiol Gastrointest Liver Physiol,2007,293(1):G403-G411.
  • 9Nadeau R J,Toher J L,Yang X,et al.Regulation of Sprouty2 stability by mam -malian Seven-in-Absentia homolog 2[J].J Cell Biochem,2007,100(1):151-160.
  • 10Lim J,Yusoff P.Wong E S,et al.The cysteine-rich sprouty translocation dom -ain targets mitogen-activated protein kinase inhibitory proteins to phosph-atidy linositol4,5-bisphosphate in plasma merabranes[J].Mol Cell Biol,2002r22(22):7953-7966.

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中医临床研究
2011年 第11期

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