干扰素2α联合吡柔比星早期膀胱灌注预防浅表性膀胱癌复发

Intravesical instillation of interferon 2α and pirarubicin for prevention of postoperative recurrence of superficial bladder cancer

目的：探讨干扰素（IFN）2α联合吡柔比星（THP）早期膀胱灌注在预防浅表性膀胱癌复发中的作用。方法：将58例浅表性膀胱癌患者随机分为A、B 2组,均行经尿道膀胱肿瘤汽化电切术。A组29例术后早期行IFN 2α联合THP膀胱灌注,2周后THP常规方案膀胱灌注;B组29例术后单纯行常规THP膀胱灌注。结果：随访24~36个月,A组复发1例,B组复发6例,A组疗效优于B组（P〈0.05）。结论：IFN 2α联合THP早期膀胱灌注与单纯术后THP膀胱灌注相比,可以更有效地减少浅表性膀胱癌复发。

Objective：To study the efficacy of early intravesical instillation of pirarubicin and interferon（IFN） 2α for prevention of postoperative recurrence of superficial bladder cancer.Methods：Fifty-eight patients with superficial bladder carcinoma treated by TURBt were divided into two groups.Group A（29 cases） were treated by early postoperative bladder instillation of pirarubicin and IFN 2α and group B（29 cases） by routine postoperative bladder instillation of pirarubicin.Results：All the cases were followed up for 24-36 months,and the recurrence rates were 3.45% in group A and 20.69% in group B.The recurrence rate of group A was lower than that of group B.The difference was significant between the two groups（P0.05）.Conclusions：Early postoperative bladder instillation of Pirarubicin and IFN 2α after TURBt is an effective method in preventing postoperative recurrence of superficial bladder cancer.