某三甲医院类风湿关节炎用药分析

Analysis of drugs for patients with rheumatoid arthritis in a certain 3A-grade hospital

目的：了解某三甲医院类风湿关节炎（RA）住院患者用药情况,探讨临床药师如何发挥作用,保障临床用药安全、经济、有效、合理。方法：抽取该医院2009年第二、三季度81例RA住院患者病历做回顾性调查,将所得到的信息根据统计学方法进行归纳、整理,分析其总量、构成比、用药频度（DDDs）值、药物利用指数（DUI）值。结果：RA患者发病年龄较高,女性多于男性,治疗疗程较长,住院花费较大。统计抗风湿病药32类,合格药品25类（DUI范围0.85~1.15）,不合格药品7类。平均出院带药6.28种,其中抗菌药物占4.91%,注射剂数占5.3%,国家基本药物占31.04%,使用通用名数占38.7%。结论：RA患者整体用药合理,但仍存在不合理用药,临床医生用药水平还需不断提高,药物使用合理性尚需加强。

Objective：To investigate the use of drugs for patients with rheumatoid arthritis（RA）in a certain 3A-grade hospital,and to explore what the clinical pharmacists could do to ensure the medicine used is safe,economic,effective and appropriate.Methods：The clinical data of 81 RA patients in the hospital during the second and third season in 2009 were surveyed retrospectively;the information obtained was summarized and sorted out;the volume dose,constituent ratio,DDDS value and DUI value were analyzed statistically.Results：The mean onset age of the patients was high,and most of them were female.The average course of treatment was quite long,and the average cost was large.The total RA drugs applied accounted to 32 kinds,25 of what were above the standard（DUI 0.85-1.15 range）,and 7 of what were not.The drugs taken out by the patients when discharged accounted to 6.28 kinds on average,among them 4.91% were antimicrobial agents,5.3% injections,31.04% essential drugs and 38.7% with general names.Conclusions：The drugs applied to RA patients are generally reasonable,but unreasonable administration still exists.Clinicians should improve their level of drug use and reinforce the rational use of drugs.