N-溴代丁二酰亚胺绿色合成工艺条件的探究

Green Synthetic Conditions of N-Bromosuccinimide

以溴酸钠、溴化钠、硫酸、丁二酰亚胺为主要原料,研究了N-溴代丁二酰亚胺（NBS）的绿色化合成工艺。优化工艺条件为：原料配比n（溴酸钠）∶n（溴化钠）∶n（硫酸）∶n（丁二酰亚胺）=1∶2∶1.7∶2.6,溶剂水90 mL,反应温度为20~40℃,反应时间为2.5 h,此条件下产品收率87%,有效溴含量为44.3%,纯度98.6%。

N-Bromosuccinimide was prepared by the reaction of sodium bromide,sodium bromide,sulfuric acid and succinimide.The process afforded the product in 87% yield,effective bromine content 44.3%,purity 98.6%[1],under the optimized reaction conditions：molar ratio n（sodium bromide）∶n（sodium bromide）∶n（acid）∶n（succinimide）=1∶2∶1.7∶2.6,water 90 mL,reaction temperature 20~40℃,reaction time 2.5 h.