中药复方灌注剂治疗奶牛乳房炎的药效与应用安全性研究

The Effecacy and Safety of Chinese Medicinal Herbs Compoud Filler for Dairy Cattle with Mastitis

治疗奶牛乳房炎的中药复方灌注剂由瓜子金、紫花地丁、鸡血藤和黄芪等11味中药组方制成。以兔子、小白鼠和豚鼠为试验动物,从镇痛、抗炎、解热、异常毒性、热源检查、溶血与凝集和过敏反应等方面进行了药效与应用安全性研究。试验显示,该中药复方灌注剂对小白鼠镇痛和抗炎效果以及对伤寒-副伤寒二联菌苗致家兔发热反应的解热效果极显著(P<0.01)。通过安全性试验,未发现该中药复方灌注剂引起异常毒性、热敏、溶血与凝集反应和过敏反应。结果表明,该中药复方灌注剂镇痛、消炎和解热效果显著,安全性较高,可用于临床试验。

The compound filler was composed of 11 kinds of the traditional Chinese herbs such as Polygala japonica,Viola yedoensis Makino,Spatholobus suberectrus and Astragalus membranaceus,etc.Rabbits,small mice and guinea pigs were selected to investigate the effecacy and safety of the compound filler through analgesic test,antiinflammation test,antipyretic test,abnormal toxicity and pyrogen test,hemolysis and agglutination reaction,and allergic reaction,etc.The results showed that the analgesic and antiinflammation effect of the compound filler in small mice and the antipyretic effect on the fever of rabbits induced by typhoid-paratyphoid vaccine were extremely significant（P0.01）.The security test revealed that the compound filler did not cause abnormal toxicity,temperature sensitivity,hemolysis and agglutination,and allergic reactions.The results indicated that the compound filler was very effective for analgesic,antiinflammation and antipyretic,and it was safe in clinical application.