丙泊酚配伍芬太尼用于无痛人流术的临床观察

Clinical observations on painless induced abortion using propofol combined with fentanyl

目的:探讨和优化丙泊酚和芬太尼用于无痛人流术的最佳配伍方案。方法:225例早孕患者按就诊次序分为4组,A组直接静脉注射丙泊酚;B、C和D组分别静脉注射0.5μg/kg,1.0μg/kg和1.5μg/kg芬太尼后注射丙泊酚。结果:A、B、C、D 4组患者中,随着芬太尼剂量依次上升,丙泊酚剂量依次下降,镇静镇痛效果依次渐佳。4组患者中仅C组镇痛镇静效果俱佳,无呼吸抑制发生和术后不良反应。结论:2 mg/kg丙泊酚配伍1μg/kg芬太尼,应用于无痛人流术,麻醉效果确切,值得临床推广。

Objective：To investigate and optimize the anaesthesia regimen of combining propofol with fentanyl for painless induced abortion.Methods：225 pregnant cases were allocated into four groups according to their order of seeing doctor.The group A was only administered with propofol,the group B,C and D were intravenously administered with propofol after giving 0.5,1.0,1.5 μg/kg fentany by intravenous injection respectively.Results：For the cases in group A,B,C and D,the dose of propofol was decreased as the fentanyl dose increasing,which reached the best analgetic and sedative effects in sequence.Among the four groups,satisfying and expected effects of analgesia and sedation were achieved in C group without respiratory depression and postoperative adverse reactions.Conclusion：Combination of 2.0 mg/kg propofol and 1.0 μg/kg fentanyl could be the optimized anaesthesia regimen to be used in painless induced abortion with definite anesthetic effect,which is worthy of being widely used in clinic.