美能片治疗抗结核药物性肝损害的疗效观察

Efficacy of compound glycyrrhizin in treatment of hepatitis induced by anti-tuberculous drugs

目的观察美能片(复方甘草酸苷)治疗抗结核药物性肝损害的临床疗效。方法将100例抗结核药物所引起的药物性肝损害患者随机分为两组,治疗组给予美能片,对照组给予肌苷片治疗,两组治疗15、30 d后进行疗效比较。结果治疗组的肝功能恢复情况明显优于对照组,两组差异有统计学意义(P<0.05);治疗组的总有效率(96%)明显大于对照组(82%),两组对比差异有统计学意义(P<0.05)。结论美能片治疗抗结核药物引起的药物性肝损害疗效显著。

Objective To study the therapeutic effect of compound glycyrrhizin on hepatitis induced by antituberculous drugs. Methods A total of 100 patients with hepatitis resulting from antituberculous agents were randomly divided into two groups：the study group was treated with glycyrrhizin and the control group was treated with inosine. The clinical efficacy of the two groups was compared after 15 days and 30 days. Results The study group showed better improvement than the control group in hepatic lesion, with significant difference between the two groups（ P 〈 0.05 ）. The total effective rate in the study group（96% ） was higher than that in the control group （ 82% ）, with significant difference between the two groups （ P 〈 0.05 ）. Conclusion Compound glycyrrhizin has remarkable effi- cacy for hepatic lesion induced by antituberculous drugs.