妊娠期高血压患者血中大血小板比率变化情况探讨

The change of larger platelet ratio in gestational hypertension

目的:探讨妊娠期高血压患者外周血中大血小板比率的变化情况及临床意义。方法:使用SYSMEX ZA7000全自动血细胞分析仪对40例正常孕妇,95例妊娠期高血压患者外周血中血小板参数进行检测,包括大血小板比率(P-LCR)、血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW),观察其变化情况。结果:妊娠期高血压疾病组PLT低于正常妊娠组(P<0.05),MPV、PDW、P-LCR高于正常妊娠组(P<0.05);重度子痫前期组PLT低于轻度子痫前期组(P<0.05),MPV、PDW、P-LCR高于轻度子痫前期组(P<0.05)。重度子痫前期组中合并症组PLT低于非合并症组(P<0.05),PDW、MPV、P-LCR高于非合并症组(P>0.05)。P-LCR与PDW、MPV相关;P-LCR与PLT相关(P<0.05)。结论:监测孕妇外周血大血小板比率变化情况在一定程度上反映妊娠期高血压的发病程度,可有望作为监测妊娠期高血压发病程度的指标之一。

Objective： To investigate the large platelet ratio changes in patients with gestational hypertension and know the clinical significance.Methods： The platelet parameters,including the large platelet ratio（P-LCR）,the total number of platelet（PLT）,mean platelet volume（MPV）,platelet distribution width（PDW） were detected by using the SYSMEX ZA7000 automated hematology analyzer in 40 normal pregnant women and 95 gestational hypertension women.Results： In gestational hypertension group the PLT was lower than that in normal pregnancy group（P0.05）,the MPV,PDW,P-LCR were higher than those in the normal group（P0.05）.Compared with the mild preeclampsia,the PLT in the severe group was lower（P0.05）,and the MPV,PDW,P-LCR were higher（P0.05）.In the severe group the PLT of the complications was lower（P0.05）,and the MPV,PDW,P-LCR were higher than those in the non-complications group（P0.05）.P-LCR and MPV,PDW were correlated;P-LCR and PLT were correlated（P0.05）.Conclusion： The changes of the P-LCR can reflect the degree of hypertension in pregnancy;the P-LCR can be expected to be an indicator of the degree of hypertension.