摘要
应用流式细胞术对８０ 例喉癌前病变细胞中的ＤＮＡ 含量进行定量检测。结果显示，２９ 例Ｉ级不典型增生中出现ＤＮＡ异倍体１ 例，３０ 例Ⅱ级不典型增生中出现ＤＮＡ 异倍体２ 例，２１ 例Ⅲ级不典型增生中出现ＤＮＡ 异倍体１１ 例。提示喉癌前病变的ＤＮＡ 异倍体率随不典型增生病变的分级增高而增加，不典型增生程度越高，癌变率越高，提示ＤＮＡ 异倍体可能是喉癌变早期的分子标志物。
The amount of DNA in precancerous cells with larynx were determined in 80 cases. One DNA heteroploid was found in 29 cases of the grade I of precancerous with larynx,2 DNA heteroploids in 30 cases of grade Ⅱ,11 DNA heteroploids in 21 cases of grade Ⅲ.This study shows that the quantity DNA heteroploid in precancersis with larynx increases as high as the grade does,and DNA heteroploid may be one of the important markers of precancersis with larynx.
