榆柏烧烫伤喷雾剂的药效学研究

Pharmacodynamic Study of Yubo Burn and Scald Spray

目的进行榆柏烧烫伤喷雾剂与其功能主治有关的药效学研究。方法采用小鼠扭体法和甩尾法分别观察榆柏烧烫伤喷雾剂的镇痛作用;运用二甲苯致小鼠耳廓肿胀模型、血管通透性试验分别评价榆柏烧烫伤喷雾剂的抗炎作用。建立Ⅱ度烫伤模型,记录小鼠背部皮肤结痂时间和创面愈合时间,并进行病理组织学观察。结果榆柏烧烫伤喷雾剂高、中、低3个剂量组与对照组比较,均具有良好的镇痛作用和抗炎作用,能明显延长小鼠的痛反应潜伏期,显著降低毛细血管通透性,减少炎症渗出,减轻水肿;具有显著提高烫伤小鼠愈合率、缩短愈合时间、提高创面愈合率、促进创面愈合的作用,对烫伤小鼠病理组织学观察的3个方面均有不同程度的改善。结论榆柏烧烫伤喷雾剂对烧烫伤皮肤有促愈合作用,且具有抗炎、镇痛作用。

Objective To perform the pharmacodynamic studies on the major efficacy of Yubo Burn and Scald Spray.Methods To observe the analgesic effects of Yubo Burn and Scald Spray with mouse writhing test and tail flick method.The xylene-induced mouse ear edema model and vascular permeability test were used to evaluate the anti-inflammatory effects of Yubo Burn and Scald Spray.The Ⅱdegree scald mouse model was established for observing the time of mouse back skin scabbing and wound healing.The histopathological observations were performed.Results Compared with the model group,3 doses groups of Yubo Burn and Scald Spray were improved to be good anti-inflammatory and analgesic effects.It can significantly prolong the pain response latency,reduce the capillary permeability,the inflammatory exudate and edema.It has the effects of improving the healing rate of burn mice,shortening healing time and promoting the wound healing,and can improve the 3 aspects of scald mouse histopathological observation.Conclusion Yubo Burn and Scald Spray can promote healing of burned and scalded skin and has anti-inflammatory and analgesic effects.