无患子皂苷对高脂血症大鼠血脂代谢的影响和对血管内皮功能的保护作用

Effects of Sapindoside on Blood Lipid Metabolism and Its Protective Action on Vascular Endothelial Function in Hyperlipidemic Rat

目的探讨无患子皂苷对高脂血症大鼠血脂代谢的影响及其血管内皮功能的保护作用。方法采用高脂饲料喂养建立大鼠高脂血症模型,同时用无患子皂苷水溶液0.486 g/(kg.d)或0.054 g/(kg.d)、辛伐他汀水溶液0.010 8 g/(kg.d)灌胃给药。第30天末从腹主动脉取血测血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙二醛(MDA)、超氧化物歧化酶(SOD)以及检测血浆前列腺素I2(PGI2)和血栓素A2(TXA2)水平。结果用药30 d后,各给药组血清中TG,TC,LDL-C,MDA和血浆中血栓素B2水平明显低于模型对照组(P<0.01),SOD和6-酮-前列腺素F1α水平明显低于模型对照组(P<0.01)。结论无患子皂苷可调节高脂血症模型大鼠血脂水平,并对血浆血栓素B2及6-酮-前列腺素F1α产生一定影响。

Objective To study the effects of sapindoside on blood lipid metabolism and its protective action on vascular endothelium function in hyperlipidemic rat.Methods The rat model of hyperlipidemia was established by high-fat forage feed.At the same time,the grouped rats were gavaged with sapindoside aqueous solution of 0.486 g/（kg·d） and 0.054 g/（kg·d） and simvastatin aqueous solution of 0.010 8 g/（kg·d）,respectively.At the end of 30 d,the abdominal aortic blood was collected and measured the serum concentration of TG,TC,LDL-C,HDL-C,MDA,SOD and the plasma level of PGI2,TXA2.Results Serum TG,TC,LDL,MDA and plasma level of TXB2 in each group after 30 d medication were significantly lower than those in the model control group（P 0.01）.Compared with the model control group,plasma levels of SOD and 6-keto-PGF1αwere significantly higher（P 0.01）.Conclusion Sapindoside plays an important role in decreasing the blood lipid of hyperlipidemia rat and has some influence on plasma TXB2 and 6-keto-PGF1α.