摘要
目的观察路优泰治疗老年抑郁症的临床疗效与安全性。方法将符合《中国精神障碍分类与诊断标准第三版(CCMD-3)》抑郁症诊断标准的老年抑郁症患者43例随机分为两组,A组20例,给予路优泰600～900 mg/d治疗,B组23例,给予丙咪嗪50～200 mg/d治疗,疗程均为6周,疗效和副反应分别采用汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)进行评定。结果 A组总有效率为70.00%,B组为78.26%,两组比较差异无统计学意义(P>0.05);A组TESS评分显著低于B组(P<0.01)。结论路优泰是一种安全有效的抗抑郁药,适用于老年抑郁症。
Objective To investigate the clinical effects and safety of neurostan on treating senile depression.Methods Forty-three patients with depressive disorders to accord with the CCMD-3 were enrolled.The examples were random divided into treatment group and control group.Hamilton Rating Scale of Depression（HAMD） and Treatment Emergent Symptom Scale（TESS） were used to evaluate the changes clinical symptoms and side effects at baseline,after treatment two weeks,four weeks and six weeks respectively.Results The total efficacy of two groups had no significant difference in HAMD scores（P 0.05）.Neurostan had less side effects than imipramine（P 0.01）.Conclusion The results suggested that the neurostan is an effective and safe antidepressant in the treatment of senile depression.
出处
《中国药业》
CAS
2011年第11期53-54,共2页
China Pharmaceuticals
关键词
老年抑郁症
路优泰
丙咪嗪
senile depression
neurostan
imipramine
